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Selank: Compound Profile of the Tuftsin-Derived Heptapeptide

By Titan Peptides Research Library · · Updated · 2 min read

Network of cultured neurons expressing green fluorescent protein, illustrating Selank neuroscience research
Photo: ManuelSchottdorf / Wikimedia Commons, CC BY-SA 4.0, cropped

Key takeaways

  • Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro: tuftsin, a fragment of immunoglobulin G, extended with a Pro-Gly-Pro tail.
  • It was designed at the Institute of Molecular Genetics of the Russian Academy of Sciences with the Zakusov Research Institute of Pharmacology, Moscow.
  • PubChem lists Selank under CAS 129954-34-3 and CID 11765600 (synonym TP-7); salt forms such as the acetate are heavier per mole.
  • With a lysine and an arginine and no acidic side chains, Selank behaves as a basic peptide when a solvent is chosen.

Selank is a synthetic seven-amino-acid peptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, built from tuftsin with a Pro-Gly-Pro tail added.1 It was developed in Russia and is not named in Australia's Poisons Standard.2

This profile describes the compound as a laboratory chemical: identity, structure, analytical checks, handling and regulation. Titan Peptides supplies it for laboratory and research use only; it is not for human consumption.

What is Selank?

Selank is a heptapeptide designed at the Institute of Molecular Genetics of the Russian Academy of Sciences, in cooperation with the Zakusov Research Institute of Pharmacology in Moscow. Its first four residues are tuftsin (Thr-Lys-Pro-Arg), a naturally occurring fragment of the heavy chain of human immunoglobulin G. The developers extended tuftsin at its C-terminus with three further amino acids, Pro-Gly-Pro, to make the molecule more resistant to breakdown by peptidases.

That Pro-Gly-Pro tail is the same "glyproline" unit found on Semax, its sister compound from the same institute. The two peptides are often mentioned together, but they are built on different parent molecules; see our Semax compound profile.

Selank at a glance

Chemical identifiers below are as listed by PubChem. Values are for the free peptide; salt forms such as selank acetate have a higher mass per mole.1

PropertySelank
ClassSynthetic heptapeptide; tuftsin analogue with a C-terminal Pro-Gly-Pro
Sequence (one-letter)TKPRPGP
Sequence (three-letter)Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular formulaC33H57N11O9
Molar mass751.9 g/mol
CAS number129954-34-3
PubChem CID11765600
Other namesTP-7
OriginInstitute of Molecular Genetics (Russian Academy of Sciences) with the Zakusov Research Institute of Pharmacology, Moscow

Selank in solution

Selank's sequence, TKPRPGP, carries a lysine and an arginine and no acidic side chains, so it counts as a basic peptide. For basic peptides, supplier guidance suggests starting with a small amount of an acidic solvent such as dilute acetic acid and then diluting to the working concentration; our reconstitution guide uses Selank as its worked example. Selank has none of the residues most prone to oxidation (methionine, cysteine, tryptophan), but routine peptide storage still applies: keep the sealed vial dry, dark and at −20 °C or colder, bring it to room temperature in a desiccator before opening, and split a stock into single-use frozen aliquots. See storing lyophilised and reconstituted peptides.

Stained neurons with branching dendrites viewed under a light microscope at 100x magnification
Photo: Ns takes photos / Wikimedia Commons, CC BY 4.0, cropped

Selank in Australia

Selank is not named in the June 2026 Poisons Standard (SUSMP No. 48).2 Whether a product is regulated as a therapeutic good depends on how it is supplied and presented; see our guide are research peptides legal in Australia?. Selank is not an approved therapeutic good in Australia.

Frequently asked questions

What is Selank?

Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. Its first four residues are tuftsin, a fragment of human immunoglobulin G, and a Pro-Gly-Pro tail was added to make it more resistant to peptidases. It was designed at the Institute of Molecular Genetics of the Russian Academy of Sciences.

What is Selank's CAS number?

PubChem lists Selank under CAS number 129954-34-3 and CID 11765600, with the synonym TP-7. For the free peptide it gives the molecular formula C33H57N11O9 and a molar mass of 751.9 g/mol; salt forms such as selank acetate weigh more per mole.

What is the structural difference between Selank and Semax?

Both are heptapeptides ending in Pro-Gly-Pro, but their parent sequences are unrelated. Selank builds on tuftsin, a fragment of immunoglobulin G; Semax builds on ACTH(4-7), a hormone fragment. Selank carries no methionine, so it is less prone to oxidation than Semax.

Is Selank legal in Australia?

Selank does not appear by name in the June 2026 Poisons Standard. The Therapeutic Goods Act 1989 defines therapeutic goods partly by presentation, so goods likely to be taken as being for therapeutic use are caught whatever their label says. Research-grade Selank is not an approved therapeutic good.

References

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 11765600, Selank. Accessed 21 September 2026. Source
  2. Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 (SUSMP No. 48), F2026L00633, commenced 1 June 2026. Federal Register of Legislation. Source
Research use only. This article summarises published scientific literature for educational purposes. It is not medical advice and does not describe or endorse human or veterinary use. Compounds supplied by Titan Peptides are for laboratory research only and are not approved therapeutic goods in Australia.

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